Yakult Forschungsinstitute

Der japanische Mikrobiologe Dr. Minoru Shirota forschte Anfang des letzten Jahrhunderts an der Universität Kyoto über die Wirkung der Darmbakterien auf die Gesundheit. Es gelang ihm, ein Milchsäurebakterium mit probiotischen Eigenschaften zu kultivieren: Lactobacillus casei Shirota.

Yakult Central Institute

Dr. Minoru Shirota gründete nicht nur das Unternehmen Yakult, sondern auch ein eigenes Forschungsinstitut, das Yakult Central Institute, in Tokyo.

Bis heute erforschen dort Wissenschaftler den Stamm Lactobacillus casei Shirota und die Darmmikrobiota. Im Jahr 2005 wurde das erste europäische Yakult Forschungsinstitut in Gent in Belgien eröffnet.

Aktuelle Publikationen der Yakult Forschungsinstitute

Shida K, Sato T, Iizuka R, Hoshi R, Watanabe O, Igarashi T, Miyazaki K, Nanno M, Ishikawa F (2017). Daily intake of fermented milk with Lactobacillus casei strain Shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle-aged office workers. Eur J Nutr 56:45-53. (PubMed)

Suzuki Y, Ikeda K, Sakuma K, Kawai S, Sawaki K, Asahara T, Takahashi T, Tsuji H, Nomoto K, Nagpal R, Wang C, Nagata S, Yamashiro Y (2017). Association between Yogurt Consumption and Intestinal Microbiota in Healthy Young Adults Differs by Host Gender. Front Microbiol 8:847. (PubMed)

Takada M, Nishida K, Gondo Y, Kikuchi-Hayakawa H, Ishikawa H, Suda K, Kawai M, Hoshi R, Kuwano Y, Miyazaki K, Rokutan K (2017). Beneficial effects of Lactobacillus casei strain Shirota on academic stress-induced sleep disturbance in healthy adults: a double-blind, randomised, placebo-controlled trial. Benef Microbes 8:153-162. (PubMed)

Yamashiro K, Tanaka R, Urabe T, Ueno Y, Yamashiro Y, Nomoto K, Takahashi T, Tsuji H, Asahara T, Hattori N (2017). Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke. PLoS One 12:e0171521. (PubMed)

Aoyagi Y, Park S, Matsubara S, Honda Y, Amamoto R, Kushiro A, Miyazaki K, Shephard RJ (2017). Habitual intake of fermented milk products containing Lactobacillus casei strain Shirota and a reduced risk of hypertension in older people. Benef Microbes 8:23-29. (PubMed)

Kato-Kataoka A, Nishida K, Takada M, Kawai M, Kikuchi-Hayakawa H, Suda K, Ishikawa H, Gondo Y, Shimizu K, Matsuki T, Kushiro A, Hoshi R, Watanabe O, Igarashi T, Miyazaki K, Kuwano Y, Rokutan K (2016). Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress. Appl Environ Microbiol 82:3649-58. (PubMed)

Arase S, Watanabe Y, Setoyama H, Nagaoka N, Kawai M, Matsumoto S (2016). Disturbance in the Mucosa-Associated Commensal Bacteria Is Associated with the Exacerbation of Chronic Colitis by Repeated Psychological Stress; Is That the New Target of Probiotics? PLoS One 11: e0160736. (PubMed)

Martin R, Makino H, Cetinyurek Yavuz A, Ben-Amor K, Roelofs M, Ishikawa E, Kubota H, Swinkels S, Sakai T, Oishi K, Kushiro A, Knol J (2016). Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota. PLoS One 11: e0158498. (PubMed)

Aizawa E, Tsuji H, Asahara T, Takahashi T, Teraishi T, Yoshida S, Ota M, Koga N, Hattori K, Kunugi H (2016). Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder. J Affect Disord 202:254-7. (PubMed)

Kato-Kataoka A, Nishida K, Takada M, Kawai M, Kikuchi-Hayakawa H, Suda K, Ishikawa H, Gondo Y, Shimizu K, Matsuki T, Kushiro A, Hoshi R, Watanabe O, Igarashi T, Miyazaki K, Kuwano Y, Rokutan K (2016). Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress. Appl Environ Microbiol 82: 3649-58. (PubMed)

Terai T, Okumura T, Imai S, Nakao M, Yamaji K, Ito M, Nagata T, Kaneko K, Miyazaki K, Okada A, Nomura Y, Hanada N (2015). Screening of Probiotic Candidates in Human Oral Bacteria for the Prevention of Dental Disease. PLoS One 10(6):e0128657. (PubMed)

Sakai T, Kubota H, Gawad A, Gheyle L, Ramael S, Oishi K (2015). Effect of fermented milk containing Lactobacillus casei strain Shirota on constipation-related symptoms and haemorrhoids in women during puerperium. Benef Microbes  6:253-62. (PubMed)

Aoki T, Asahara T, Matsumoto K, Takada T, Chonan O, Nakamori K, Nonaka C, Yamaji I, Hisamoto T, Sato M, Matsuda T, Nomoto K (2014). Effects of the continuous intake of a milk drink containing Lactobacillus casei strain Shirota on abdominal symptoms, fecal microbiota, and metabolites in gastrectomized subjects. Scand J Gastroenterol 49(5):552-63. (PubMed)